Actionable Variants                                                                                         Damaging : An alteration with an effect on proteinfunction (gain, loss or altered) based on several publications by differentresearch groups which include some clinical information
​Probably Damaging : An alteration with an effect on proteinfunction based on only one publication and perhaps only using an in vitromodel and for which no clinical information is available
​Unknown : Analteration with no demonstrated effect on protein function  

Variants of Uncertain Significance (VUS)                                                                    An alteration with no demonstratedeffect on protein function 

MedicallyActionable Incidental Findings                                                                     An alteration that might be associatedwith a genetic disease or increase susceptibility with some cancer. 

Probably Polymorphism                                                                                               An alteration characterized as polymorphism with a minor allele frequency (MAF) ≥1% and not associated with any genetic disease.